PRISMS is dedicated to providing information and support to families of persons with Smith-Magenis Syndrome (SMS), sponsoring research and fostering partnerships with professionals to increase awareness and understanding of SMS.
PRISMS has compiled a list of resources that we hope you will find helpful as you cope with the impact of the coronavirus pandemic.
Please see the COVID-19 Resources page for more information.
Are you associated with someone who has been newly diagnosed with Smith-Magenis Syndrome?
Become part of the PRISMS community
Sign up to get the latest information and resources from PRISMS and the Smith-Magenis Syndrome community.
Connect with other local families
Connect with your local Regional Representative to help connect you with other SMS families in your area.
You are embarking on a difficult journey, but one that is rewarding.
You will grieve when your child struggles, but you will revel in their accomplishments.
What is SMS?
Smith-Magenis syndrome (SMS) is a rare neurobehavioral disorder characterized by a recognizable pattern of physical, behavioral, and developmental features. It is caused by particular genetic changes on chromosomal region 17p11.2, which contains the gene RAI1. MORE >
What Treatment is Available?
There are no medications that can “cure” SMS or eliminate the core symptoms. However, there are medications that can help some people with SMS function better. For example, medication might help manage high energy levels, inability to focus, or seizures. MORE >
How Rare is SMS?
Although the exact incidence is not known, it is estimated that SMS occurs in about 1/15,000 to 1/25,000 births. SMS is under-diagnosed, but as awareness of the syndrome increases, the number of people identified grows each year. MORE >
How is SMS Diagnosed?
The diagnosis of Smith-Magenis Syndrome (SMS) is usually confirmed through a clinical blood test called a chromosome analysis. Diagnosis can also be made through a cytogenetic test and FISH (fluorescence in situ hybridization) or by chromosome microarray analysis (CGH). MORE >
Our continued efforts depend on donations and gifts from people like you. Won’t you help?
Recent SMS News
- What does the Professional Advisory Board do for PRISMS?
Our work at PRISMS would not be possible without the expertise of our amazing Professional Advisory Board, also known as the PAB. The PAB consists of ten individuals representing the diverse needs of the Smith-Magenis…See More >
- SMS Teen Spreads Cheer as Special Fester for Oktoberfest Celebration
By: Kimberly Caulkins Every year since 1961 the city of La Crosse, Wisconsin holds a traditional German Oktoberfest. Born in Munich in the 19th century, Oktoberfest first made its way to La Crosse in 1961.…See More >